Acknowledgments

This work was supported by the Russian Federal Property Fund, project 17-06-00954-OGN "Comprehensive topical diagnosis of cognitive disorders in essential arterial hypertension

Table 1. Patients with arterial hypertension (AH) and healthy individuals with signs of a decrease in cognitive activity (%)

Assessment Parameter	Group
	Patients with AH	Healthy Individuals
Thinking	82**	20
Memory (direct memorising)	16*	12
Memory (indirect memorising)	84**	24
Attention	84**	36

NB: differences between groups are: * – р≤0,05; ** – р≤0,001. 

Fig. 1. The frequency of attention disorders in groups in patients with arterial hypertension (AH) and healthy individuals (%)

NB: differences between groups are: ** - p≤0.001.

Table 2. The frequency of occurrence of impaired natural auditory-speech memory (direct memory) in patients with arterial hypertension (AH) and in healthy individuals (%)

Assessment Parameter	Groups
	Patients with AH	Healthy Individuals
Reduced memory (less than 4 items reproduced)	19**	8
Sawtooth Curve	32*	16
Plate Curve	8	0
Contamination	3	0
Decreased amount of delayed auditory-speech memory (Decreased memory productivity)	19**	4
Paraphases	31**	16

NB: differences between groups are: * – р≤0.05; ** – р≤0.001.

Fig. 2. Average values of the erroneous decisions according to the “Progressive Raven’s Matrices” in patients with arterial hypertension (AH) and healthy individuals

NB: differences between groups are: * – р≤0.05; ** – р≤0.001.

Table 3. Mean value of the emotional-personal sphere in patients with arterial hypertension (AH) and healthy individuals

Assessment Parameter	Group
	Patients with AH	Healthy Individuals
A » Heartiness / Alienation (Cattel Test)	4.63*	5.59
F Expressiveness / Restraint (Cattel Test)	3.22*	4.36
Shock reaction (Pictogram)	4.93**	2.08
Hatching Pattern (Pictogram)	0.43**	0.01
Repeated Pinpointing (Pictogram)	4.54**	1.13
Anxiety (Hamilton Scale)	2.12**	0.05
Depression (Hamilton Scale)	0.96**	0,05

NB: differences between groups are: * – р≤0,05; ** – р≤0,01.

Fig. 3. Correlation relationship between the assessment parameters of cognitive activity and the emotional and personal characteristics of patients with arterial hypertension (AH)

Legend: dashed line – negative connection, solid line – positive connection, green – Cattel Test, purple – Pictogram, black – IQ (Raven’s Matrices), light-blue - error in each series of "Progressive Raven’s Matrices", red - severity of anxiety (Hamilton scale).

Fig. 4. Correlation between anxiety, depression and cognitive performance in patients with arterial hypertension (AH)

Legend: dashed line – negative connection, solid line – positive connection, green – Schulte table, orange – memory, 10 words technique, purple - Pictogram, black - severity of depression (Hamilton scale), light-blue - error in each series of "Progressive Raven’s Matrices", red - severity of anxiety (Hamilton scale).

References:

Asmolov A.G. (2011). Psychology of Personality. Cultural and historical understanding of human development. Moscow, Smysl. 

Bleicher V.M., Kruk I.V., & Bokov S.N. (2002). Practical pathopsychology. Moscow; Voronezh: MODEK.

Broytigam V., Christian P., & Rad M. (1999). Psychosomatic medicine: textbook. Moscowб Meditsina.

Buklina S.B. (2019). Disturbances of higher mental functions with damage to the deep and stem structures of the brain. Moscow, MEDpress-inform,

Buklina S.B. (1999). Memory impairment and deep brain structures. [Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova],9, 10–15.

Carlson S.H., & Wyss J.M. (2011). Mechanisms Underlying Hypertension and Obesity: A Melanocortin Linkage in the Brain. Hypertension, 57, 375–376. doi: 10.1161/HYPERTENSIONAHA.110.161729

Cattell H. E., & Schuerger J. M. (2003). Essentials of the 16PF. NY.: John Wiley & Sons,

Cerhan J.R., Folsom A.R., Mortimer J.A., Shahar E., Knopman D.S., McGovern P.G., Hays M.A., Crum L.D., & Heiss G. (1998). Correlates of cognitive function in middle-aged adults: Atherosclerosis Risk in Communities (ARIC) Study Investigators. Gerontology,44, 95–105. doi: 10.1159/000021991

Cohen R.A. (2011). Neuroimaging of cardiovascular disease. In R.A. Cohen & L.H. Sweets (Eds.), Brain Imaging in Behavioral Medicine and Clinical Neuroscience. New York: Springer, 215–256. doi: /10.1007/978-1-4419-6373-4_15

Davidovich I.M., Afonaskov O.V., & Staroverova Yu.K. (2009). The state of memory, attention and thinking in young males with arterial hypertension. [Sistemnye gypertenzii]. 4, 59–63.

Davydov D.G., & Chmykhova E.V. (2016). Application of the test “Raven’s Standard progressive matrices” in the time limit mode. [Voprosy Psikhologii], 4,129–139.

Denollet J. (2000). Type D personality. A potential risk factor defined. J Psychosom Res, 49, 255–266. doi: 10.1016/S0022-3999(00)00177-X

Dima-Cozma C. et al. (2014). Socioeconomic status and psychological factors in patients with essential hypertension. In Dima-Cozma C., Mitu F., Szalontay A., & Cojocaru D.-C. Revista de CercetaresiInterventieSociala, 44, 147–159.

Douglas K. M., Porter R. J., Knight R. G., & Maruff P. (2011). Neuropsychological changes and treatment response in severe depression. British journal of psychiatry. Vol. 198, 115–122. doi: 10.1192/bjp.bp.110.080713

Dregan A., Stewart R., & Gulliford M.C. (2013). Cardiovascular risk factors and cognitive decline in adults aged 50 and over: a population-based cohort study. Age Ageing, 42, 338–345. doi: 10.1093/ageing/afs166

Dunbar F. (1954). Emotions and bodily changes. N.Y.: Columbia Univ. Press.

 Gotlib H., & Joormann J. (2010). Cognition and Depression: current status and future directions. Annual revue clinical psychology, 6, 285–312. doi: 10.1146/annurev.clinpsy.121208.131305

Grabe H. J., Schwahn C., & Barnow S. (2010). Alexithymia, hypertension, and subclinical atherosclerosis in the general population. J. Psychosom. Res, 68, 139–147. doi: 10.1016/j.jpsychores.2009.07.015

Grace W. J., & Gracham D. T. (1952). Relationship of specific attitudes and emotions to certain bodily diseases. Psychosom. Med., 14, 243–251. doi: 10.1097/00006842-195207000-00001

Hamer M. (2010). Adherence to healthy lifestyle in hypertensive patients: ample room for improvement? Journal of Human Hypertension, 24, 559–560. / doi: 10.1038/jhh.2010.61

Hamilton M. (1960). A rating scale for depression. Journal of Neurology, Neurosurgery and Psychiatry, 23, 56–62.  doi: 10.1136/jnnp.23.1.56

Hamilton M. (1959). The assessment of anxiety states by rating. Br J Med Psychol, l(32), 50–55. doi: 10.1111/j.2044-8341.1959.tb00467.x

Hausteiner C., Klupsch D., Emeny R., Baumert J., & Ladwig K. (2010). Clustering of negative affectivity and social inhibition in the community: prevalence of type D personality as a cardiovascular risk marker. Psychosom. Med, 72, 163–171.  doi: 10.1097/PSY.0b013e3181cb8bae

Henrique C. S., Muela H. C., Costa-Hong V. A., Yassuda M. S., Moraes N. C., Memória C. M., Machado M. F., Macedo T. A., Shu E. B., Massaro A. R., Nitrini R., Mansur A. J., & Bortolotto L. A. Hypertension severity is associated with impaired cognitive performance. J. Am. Heart. Assoc. Severity, 6, e004–579.

Hughes T.M., & Sink K.M. (2016). Hypertension and Its Role in Cognitive Function: Current Evidence and Challenges for the Future. American Journal of Hypertension,  29(2), 149–157. doi: 10.1093/ajh/hpv180

Iadecola C., Yaffe K., Biller J., Bratzke L.C., Faraci F.M., Gorelick P.B., Gulati M., Kamel H., Knopman D.S., Launer L.J., Saczynski J.S., Seshadri S., Zeki A., & Hazzouri A. (2016). Impact of Hypertension on Cognitive Function: A Scientific Statement From the American Heart Association. Hypertension, 68(6), e67–e94. doi: 10.1161/HYP.0000000000000053

Jennings J.R., & Heim A.F. (2012). From brain to behavior: hypertension's modulation of cognition and affect. Int J Hypertension. Article ID 701385. doi: 10.1155/2012/701385

Kapustina A.N. (2006). Multifactorial personality technique of R. Cattel: textbook. St. Petersburg, Rech.

Khersonskiy B.G. (2000). Method of pictograms in psychodiagnostics. St. Petersburg, Sensor, 128.

Khomskaya E.D. (1987). Neuropsychology. Moscow, Izdatel’stvo Moskovskogo Universiteta.

Korsakova N.K., & Varako N.A. (2005). On the determinants of the formation of neurocognitive disorders in arterial hypertension at a later age. [Vestnik Moskovskogo universiteta]. Series 14, Psychology, 4, 16–23.

Korsakova N.K., & Moskovichute L.I. (1988). Clinical neuropsychology. Moscow, Izdael’stvo Moskovskogo Universiteta.

Korsakova N.K., Ostroumova O.D., Varako N.A., Mamaev V.I., Nesterova M.V., & Martynov A.I. (2001). The effect of long-term therapy with fosinopril and amlodipine on the memory of elderly patients with mild and moderate essential arterial hypertension. Kardiologiya,  41(8), 47–51.

Korsakova N.K., & Roshchina I.F. (2018). The concept of A.R. Luria on the three functional blocks of the brain and the neuropsychological syndrome of normal aging. In N.V. Zvereva, I.F. Roschina (Eds.) [Metodologicheskie i prikladnye problemy meditsinskoy (klinicheskoy) psikhologii: kollektivnaya monografiya]. Moscow, Sam Poligrafist, 203–211.

Kochenov M.M., & Nikolaeva V.V. (1978). Motivation for schizophrenia. Moscow, Izdael’stvo Moskovskogo Universiteta.

Krzesinski J., & Leeman M. (2011). Practical issues in medication compliance in hypertensive patients. Research Reports in Clinical Cardiology,  2, 63–70.

Leontiev A.N. (1975). Activity. Consciousness. Personality.  Moscow, Politizdat.

Longinova S.V. (1998). The study of thinking inpatients using the method of "pictograms". In N.L. Belopolskaya (Ed.) [Patopsikhologiya: Khrestomatiya]. Moscow, Izdatel’stvo URAO, 96–108.

Luria A.R. (1969). Higher cortical functions of a person and their disturbances in local brain lesions. Moscow, Izdatel’stvo Moskovskogo Universiteta.

Luria A.R. (1976). Neuropsychology of memory. In 2 vols. Vol. 2. Memory impairment in deep brain lesions. Moscow, Pedagogika,

Luria A.R. (1973). Fundamentals of Neuropsychology. Moscow, Izdatel’stvo Moskovskogo Universiteta.

Mendelevich V.D., & Solovieva S.L. (2002). Neuroscience and psychosomatic medicine. Moscow, Medpress-Inform.

Mann S.J. (2012). Psychosomatic Research in Hypertension: The Lack of Impact of Decades of Research and New Directions to Consider. The Journal of Clinical Hypertension,  14(10), 657–664. doi: 10.1111/j.1751-7176.2012.00686.x

Moritz S., Birkner C., Kloss M., Jahn H., Hand I., Haasen C., & Krausz M. (2002). Executive functioning in obsessive-compulsive disorder, unipolardepression, and schizophrenia. Archives of Clinical Neuropsychology, 17, 477–483. doi: 10.1093/arclin/17.5.477

Nekrasova E.M. (1987). Features of cognitive activity and the emotional-personal sphere in patients with arterial hypertension in early and reversible forms of cerebrovascular accident: Ph.D. in Psychology, Thesis. Moscow, 231.

Obisesan T.O., Obisesan O.A., Martins S., Alamgir L., Bond V., Maxwell C., & Gillum R.F. (2008). High blood pressure, hypertension, and high pulse pressure are associated with poorer cognitive function in persons aged 60 and older: the Third National Health and Nutrition Examination Survey. J Am Geriatr Soc, 56, 501–509. doi: 10.1111/j.1532-5415.2007.01592.x

Ostroumova O.D., Korsakova N.K., & Varako N.A. (2009). Arterial hypertension in the elderly and the state of higher mental functions. The possibilities of antihypertensive therapy arifonometard in the prevention of dementia. [Sistemnye gipertenzii], 4, 63–66.

Ostroumova O.D., Pervichko E.I., & Zinchenko Yu.P. (2016). Psychological characteristics of patients with stress-induced arterial hypertension: dysregulation of emotions as a central link in pathogenesis. Kardiologiya, 9, 40–49. doi: 10.18565/cardio.2016.9.40-49

Ostroumova T.M., Parfenov V.A., & Ostroumova O.D. (2017). Arterial hypertension and cognitive impairment: a view from the perspective of evidence-based medicine. [Neyrologiya, neyropsikhiatriya, psikhosomatika], 9(4), 70–76. doi: /10.14412/2074-2711-2017-4-70-76

Parfenov V.A., Ostroumova T.M., Ostroumova O.D., Perepelov V.A., & Perepelova E.M. (2018). Diffusion-tensor magnetic resonance imaging in the diagnosis of damage to the white matter of the brain in middle-aged patients with uncomplicated essential arterial hypertension. [Neyrologiya, neyropsikhiatriya, psikhosomatika],10(2), 20–26.  doi: 10.14412/2074-2711-2018-2-20-26

Pervichko E.I. (2016). Regulation of emotions in patients with cardiovascular diseases: Doctoral Thesis. Moscow.

Pervichko E., Ostroumova T., Darevskaya M., Perepelova E., Perepelov V., Vartanov A., Kozlovskiy S., Ostroumova O., Parfenov V., & Zinchenko Y. (2018). A psychophysiological study of cognitive disorders in naïve middle-age patients with uncomplicated essential hypertension and white matter lesions. European Psychiatry. V. 48, 114.

Popov Yu.V., & Pichikov A.A. (2012). Early diagnosis of anxiety-phobic disorders in adolescents in general medical practice. Guidelines. St. Petersburg: NIPNI imeni V.M. Bekhtereva.

Raven J., Raven J.K., & Cort J.H. (2012). A Guide to Raven's Progressive Matrices and Vocabulary Scales. Moscow, Kogito Tsenter. doi: 10.1037/t10910-000

Raven J., Raven J.C., & Court J.H. (2003). Manual for Raven's Progressive Matrices and Vocabulary Scales. San Antonio, TX: Harcourt Assessment.

Rubinstein S.L. (1989). Bases of General Psychology. In 2 vols. Vol. 2. Moscow, Pedagogika.

Rubinstein S.Ya. (1970). Experimental methods of pathopsychology and the experience of their use in the clinic: a practical guide. Moscow, Meditsina.

Rukavishnikov A.A., & Sokolova M.V. (1995). R. Cattell-95 factor personality questionnaire: usage guide. St. Petersburg, Imaton.

Rutledge T., & Hogan B.E. (2002). A quantitative review of prospective evidence linking psychological factors with hypertension development. Psychosom. Med, 64, 758–766. doi: 10.1097/01.PSY.0000031578.42041.1C

Saxby B.K., Harrington F., McKeith I.G., Wesnes K., & Ford G.A. (2003). Effects of Hypertension on Attention, Memory, and Executive Function in Older Adults. Health Psychology, 22(6), 587–591. doi: 10.1037/0278-6133.22.6.587

Sinkova G.M. (2007). Epidemiology of arterial hypertension. [Sibirskiy Meditsinskiy Zhurnal], 8, 5–10.

Sokolov E.I., Ostroumova O.D., Pervichkov E.I., Guseva T.F., & Baryshnikova Z.M. (2005). Psychological and hemodynamic characteristics of patients with arterial hypertension during emotional stress. [Arterial’naya gipertenziya], 11(1), 29–35. /doi: 10.18705/1607-419X-2005-11-1-29-33

Sorokin A.V., Grigoricheva E.A., & Evdokimov V.V. (2016). Disadaptive reaction and the development of arterial hypertension in conditions of occupational stress. [Kardiologiya], 7, 20–24.  doi: 10.18565/cardio.2016.7.20-24

Tkhostov A.Sh., Akhutina T.V., & Balashova E.Yu. et al. Round table "Problems and prospects of the psychological study of violations of arbitrary regulation of activity". In N.K. Korsakova, Yu.V. Mikadze (Eds.). [Nasledie A.R. Lurii v sovremennom nauchnom i kul'turno-istoricheskom kontekste: K 110-letiyu so dnya rozhdeniya A.R. Lurii: sbornik].  Moscow, Fakul'tet psikhologii MGU imeni M.V. Lomonosova, 286–327.

Williams J.B.W. (1989). A structured interview guide for the Hamilton Depression Rating Scale. Archives of General Psychiatry, 45, 742–747. doi: 10.1001/archpsyc.1988.01800320058007

Zakharov VV, & Vakhnina N.V. (2013). Cognitive impairment in hypertension. [Nervnye bolezni], 3, 16–21.

Zeigarnik B.V. (1962). Pathology of thinking. Moscow, Izdatel’stvo Moskovskogo Universiteta.

Zeigarnik B.V. (1986). Pathopsychology. Moscow, Izdatel’stvo Moskovskogo Universiteta.

Zinchenko Yu.P., & Pervichko E.I. (2016). Clinical and psychological study of the regulation of emotions: cultural-activity approach. [Voprosy Psikhologii], 3, 41–57.