Association to dopamine receptor D2 (DRD2) with developing fatigue as a result of long-term cognitive load

Polikanova, Irina S. Lomonosov Moscow State University

Korshunov, Alexey V. Institute of Physical Culture, Sport and Health, Moscow State Teacher-Training University

Leonov, S.V. Lomonosov Moscow State University

Veraksa, A.N. Lomonosov Moscow State University, Federal Scientific Center of Psychological and Multidisciplinary Research

Table 1. HAM Method (DRD2)

	Health	Activity	Mood	Total
A1+	5,4/4,4**	5,1/4**	5,4/5,2	5,3/4,5**
A1-	5,5/4,7**	5/4,3**	5,4/5,2	5,3/4,8**
Before/After Fatigue, Scale: 1-7 points

Table 2. Common Hand-Eye Response

DRD2	Before Fatigue, ms (st.dev.)	After Fatigue, ms (st.dev)
A1+	221,9 (16,4)	227,6 (14,4)
A1-	232,3 (21,1)	243,6 (30)*

*Significant changes (p≤0,05)

Table 3. Choice Reaction

	Response Time, ms		Errors
DRD2	Before Fatigue	After Fatigue	Before Fatigue
A1+	400,2 (43,9)	377,9 (44,9)**	6,1
A1-	430,1 (60,1)	413,6 (59,5)*	6,1

* Significant changes (p≤0,05);

** significant changes (p≤0,01)

Table 4. Maximum Tapping

DRD2	Before Fatigue, ms	Before Fatigue, ms
A1+	170(16)	175(12)
A1-	175(18)	172(19)

Table 5. Index alpha frequency (IAF) Before/After Fatigue in DRD2

Brain Parts	(IAF, Hz/ st.dev.)
	«A1+» Group		«A1-» группа
	Before Fatigue	After Fatigue	Before Fatigue	After Fatigue
Left Lobe	10,10 (0,88)	9,53 (1,02)*	9,63 (0,96)	9,69 (1,01)
Right Lobe	10,06 (0,87)	9,43 (1,06)*	9,77 (0,96)	9,72 (1,08)
Central Left Lobe	9,84 (0,70)	9,45 (1,10)	9,75 (0,98)	9,77 (1,10)
Central Right Lobe	9,77 (0,79)	9,30 (1,07)*	9,73 (1,03)	9,68 (1,03)
Parietal Left Lobe	9,89 (0,85)	9,68 (0,97)	9,96 (0,99)	10,04 (1,04)
Parietal Right Lobe	10,23 (0,43)	9,73 (0,74)	10,10 (1,02)	10,01 (0,99)
Temporal Left Lobe	9,96 (0,92)	9,69 (1,14)*	9,81 (0,95)	9,73 (0,96)
Temporal Right Lobe	10,18 (0,51)	9,60 (0,91)*	9,89 (0,93)	9,80 (0,96)
Occipital Left Lobe	10,14 (0,82)	9,57 (0,77)*	9,97 (1,05)	9,90 (0,97)
Occipital Right Lobe	10,35 (0,53)	9,69 (0,70)*	10,01 (0,98)	9,90 (0,90)

* significant changes (p≤0,05);

** significant changes (p≤0,01)

Table 6. Fatigue Index Before/ after Fatigue in DRD2

Brain Parts	(IAF, Hz/ st.dev.)
	«A1+» Group		«A1–»Group
	Before Fatigue	After Fatigue	Before Fatigue	After Fatigue
Left Lobe	3,72 (2,32)	4,18 (2,82)	4,65 (3,00)	5,18 (3,15)
Right Lobe	6,31 (2,84)	7,12 (3,32)*	7,27 (2,65)	7,77 (2,46)
Central Left Lobe	2,66 (1,40)	3,27 (1,72)	3,59 (2,81)	4,36 (2,45)
Central Right Lobe	2,78 (1,34)	4,16 (2,58)**	3,62 (2,95)	4,97 (2,57)**
Parietal Left Lobe	3,37 (2,91)	4,42 (3,41)	3,66 (3,09)	5,31 (3,04)**
Parietal Right Lobe	4,58 (4,17)	5,78 (5,02)	5,00 (3,90)	6,56 (3,89)**
Temporal Left Lobe	2,49 (1,38)	3,96 (2,74)*	3,26 (2,46)	4,10 (2,33)*
Temporal Right Lobe	2,97 (3,25)	3,92 (3,85)*	3,24 (2,15)	4,26 (2,70)*
Occipital Left Lobe	3,14 (2,40)	4,44 (3,88)*	3,97 (3,08)	4,62 (2,57)*
Occipital Right Lobe	3,11 (2,63)	4,38 (3,69)*	3,56 (2,58)	4,40 (2,27)*

* significant changes (p≤0,05);

** significant changes (p≤0,01)

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